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5,6 Mechanistic investigations have revealed that SLC22A4 is not ubiquitously expressed

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Among them, the allele frequency of Q141K , V12M , and Q126X is 31.9, 19.2, and 2.8% (Matsuo et al., 2009)

[Google Scholar] 49.Liu S, Wang Y

Theoretically, the two compounds target completely different receptor systems (amylin receptors for cagrilintide, GLP-1/GIP/glucagon for retatrutide), which suggests they could work synergistically without receptor overlap

Here, we discuss both the canonical and non-canonical functions of glycolytic enzymes and evaluate their potential as therapeutic targets in AML