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Current serotonin medications are aimed at increasing central 5-HT neurotransmission in the brain, and there are no approved indications for manipulating peripheral 5-HT, though peripheral 5-HT synthesis is being considered as a potential target for developing pharmacological agents in some disorders (8, 9)

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McIlduff 2011)

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For general wellness, once a month might be ideal, while athletes or those recovering from illness may require more frequent sessions

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