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Okamoto N, Yoshino K, Kitagawa S, Fujii R, Hamada S, Ikenouchi A, et al

Additionally, our study identified novel loci and variants that have not been reported in earlier GWAS

This requires instrumentation that can provide the necessary data, as well as analysis of existing data from current detection systems, such as those on the lunar surface (207) or in other locations (208)

The identified variants result in a loss-of-function of GPX4 through deletion or duplication resulting in a frameshift and premature truncation of the protein

Previous studies have also demonstrated that various chronic stress triggers hyperalgesia and allodynia [10, 11]

doi: 10.1016/j.amjmed.2019.03.023