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As an alternative methyl donor, betaine plays a central role in maintaining methylation capacity, and its depletion may contribute to elevations in S-adenosylhomocysteine and impaired methyltransferase activity

pmid:25831508 101

J Pain Symptom Manag 35(1):3139 Hammack JE, Michalak JC, Loprinzi CL, Sloan JA, Novotny PJ, Soori GS, Tirona MT, Rowland KM, Stella PJ, Johnson JA (2002) Phase III evaluation of nortriptyline for alleviation of symptoms of cis-platinum-induced peripheral neuropathy

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Ulland TK, Colonna M
