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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges ( in vivo may be lower, exposure continues for a prolonged period as the half-life of DEAQ is 10 to 12 days ( The relative contribution of GSTP1 to GSH-conjugation of both QIs was highest at GSH-depleted conditions, while in absolute quantities a higher GSTP1-dependent increase of GSH conjugate formation was seen without BSO pre-treatment ( Figure 5 )

Therefore, adolescents with obesity may be at a higher risk of ID because of unbalanced meals, which are high in calories but low in iron, whether absolute or relative to body mass, together with increased iron needs

Characteristics of all patients combined The extracellular and intracellular redox balance, as measured by GSH and GSSG levels, differs between asthma and controls BAL fluid

doi: 10.1186/s40164-020-00196-w 120 WangQLibertiMVLiuPDengXLiuYLocasaleJWet al

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Dupont, N