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(Yu et al., 2020) induced gene silencing and overexpression of ubiquitin-specific protease 15 (USP15) in degenerative NPCs and found that USP15 was upregulated in degenerative NPCs and that its overexpression accelerated the process of apoptosis

Since several mutations are induced by chemicals, it is worthwhile to develop alternative screening methods, such as robust in silico methods to predict chemically induced mutagenicity 26
