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Also, in the long term, high CO 2 is associated with a decrease in expression of genes encoding proteins involved in S acquisition such as sulfate transporters, and enzymes of glutathione metabolism 43

Ubiquitin-dependent lysosomal degradation of GPCRs and long-term desensitization GPCR ubiquitination, as shown initially for the 2 AR and the chemokine receptor CXCR4, is a critical tag that directs internalized receptors to lysosomes, although initial agonist-induced endocytosis of these receptors does not require receptor ubiquitination [70, 77]