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Primary Handling Editor: Yanina-Yasmin Pesch, in collaboration with the Nature Metabolism team

Only one retrospective human clinical study has been published

Black men are stopped and searched at nine times the rate of white men

Typical combination protocols run 6 to 12 weeks, depending on the condition being treated and the patient's response

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Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction