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demonstrated in a macrophage-specific IGF-1 Apoe -/- mouse model that macrophage-derived IGF-1 inhibited the expression of chemokine (C-X-C motif) ligand 12 (CXCL12), reduced monocyte recruitment to plaques, and favoured macrophage cholesterol efflux (60)

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I am not extremely overweight, but my goal is to lose 20 pounds