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Pralatrexate: 1 (milligram) mg of vitamin B12 as an injection no more than 10 weeks prior to the first dose and every 8 to 100 weeks thereafter

For some, this can be a more comfortable option with less potential for soreness at the injection site

These are not safety findings they are gaps in the safety dataset

Refrigeration is optional but can extend shelf life

It is typically not recommended for self-administration due to the smaller muscle mass compared to other sites

The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2