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Because the peptide potently and aggressively stimulates angiogenesis via the VEGF/VEGFR2 pathways, there is a theoretical, but highly biologically plausible, risk that BPC-157 could inadvertently supply massive new blood flow to existing, undiagnosed malignant tumors, thereby acting as a catalyst for rapid cancer metastasis

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doi: 10.3390/brainsci10121013 100 HuangY.-Y.KandelE

Immune checkpoint blockade (ICB) agents, such as antibodies that inhibit PD-(L)1 or CTLA-4, have been used with success in the treatment of many cancers, including NSCLC [117]

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