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N-acetylcysteine administration: (a) induced the Nrf2-ARE system, lowering the hippocampal oxidative stress assessed as the ratio of oxidized glutathione (GSSG)/reduced glutathione (GSH)

Rhabdomyosarcoma is the most common soft tissue sarcoma in the pediatric population, arising from immature mesenchymal cells committed to skeletal muscle differentiation

Rescue of cells from apoptosis by inhibition of active GSH extrusion

Briefly, metabolites from 1.0-3.0 10 6 CAR T cells were extracted using 0.4 mL of solvent mixture (water: methanol: acetonitrile, 1:2.25:0.75, v/v/v) and 3 freeze-thaw (30 s each) cycles

One way it does this is by measuring levels of an essential antioxidant called glutathione

2023b;44(3):393416