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CD36 upregulates PD-L1 via peroxisome proliferator-activated receptor gamma (PPAR) signaling, creating dual resistance through lipid metabolism-immune checkpoint crosstalk (114).Targeting this pathway (via CD36 blockade or nano-delivery) can restore T cell function and overcome resistance

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Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma

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As a result, gastrointestinal inflammation increases and is known to cause gastritis and increase the risk of developing stomach cancer

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