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An explorative novel approach is to target dyslipidemia using a variation of the CRISPR-Cas9 platform permanently downregulating Angptl3 by introducing non-sense mutations [233]

Vynnytska-Myronovska B, Bobak Y, Garbe Y, Dittfeld C, Stasyk O, Kunz-Schughart LA

WormBook 114 (2005)

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Addisons disease usually causes diffuse hyperpigmentation of the skin and mucosa but our patient displayed the typical cobblestone pattern hyperpigmentation confined to fungiform papillae on the lateral tongue which could be considered as PFPT