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Indeed, in these studies, APR-246 was administrated for 7 to 28 days, and reduction of tumor volume after 4 days of treatment was minimal at best

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QJM 93:341349 Schidt FV, Lee WM, Bondesen S, Ott P, Christensen E (2002) Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose