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J Inflamm (Lond) (2021) 18:2

Author contributions CS, MA, EA and LB contributed to the design of the study, execution of the experiments and writing of the manuscript

If it does not work, nobody finds out through a phase 3 readout

That means: Hypokalemia can develop or worsen which can lead to: Cardiac arrhythmias Muscle weakness QT prolongation In severe cases, sudden cardiovascular instability This is a classic board-style pearl that many clinicians forget because B12 feels benign. But in profoundly deficient patientsespecially those with severe megaloblastic anemiarepletion is metabolically active treatment

These effects, when present, are typically manageable and resolve with continued use or dose adjustment

But it can only bind to those receptors if its molecular shape remains intact