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However, when tBuOOH concentration was 1.5 mM, a meaningful increase in cells volume was recorded: the MCV was 111.4 fL (95.4124.3) median, which was 1.32 times higher than the MCV of untreated cells (Fig
It supports the removal of damaged collagen and the production of new, healthy collagen

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PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase
Despite these side effects, the overall benefits in weight and diabetes control make oral semaglutide a promising addition to the arsenal of weight loss medications

J Biol Chem (2013) 288:25098108
