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10.1038/cddis.2012.46 Cell Death Dis

Biology of MDD: Elevated MAO-A Levels in the Brain While the monoamine theory of depression suggests that monoamine levels are lowered in depression, it does not explain how monoamine lowering takes place.22 Because the enzyme MAO-A metabolizes and regulates serotonin, norepinephrine, and dopamine in the brain, it is a logical contributor to the pathophysiology of depression.22,23 Meyer et al22 studied 17 healthy individuals and 17 individuals with MDD to determine if MAO-A levels in the brain are elevated during episodes of untreated depression

On the other hand, the pathophysiology of type 1 diabetes mellitus (T1DM), which accounts for 10% of all cases of diabetes, classically involves the autoimmune destruction of -cells in the pancreas by invading CD4+ and CD8+ T-cells and macrophages

This inconsistency can complicate literature reviews and meta-analyses

DISCLOSURES Dr

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