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Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3K and PI3K for the treatment of PTEN-deficient cancers

Solution stable 14 to 28 days at 2 to 8 C in a dark vial

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Consistent with this result, affinity-selection mass spectrometry (AS-MS) 25,26,27 showed a reduction in bound berberine (Fig