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Of notice is that seizure decline was rapid for KD and MAD, while more gradual for LGI
performance is pH-dependent

Because it is a small molecule that passively diffuses across the intestinal lining, it does not rely heavily on microbial metabolism in the gut

Activated Caspase-1 then cleaves Gasdermin D (GSDMD), releasing its N-terminal pore-forming region (GSDMD-N) to form membrane pores, and simultaneously processes pro-IL-1 and pro-IL-18 into their mature, active forms (41)
