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At least five variants of GPx are known to be selenoproteins: GPx1 (in the cytosol) GPx2 (specific to epithelial cells in the lungs and intestinal lining) GPx3 (thyroid and kidneys) GPx4 (phospholipid-hydroperoxide) and GPx6 (active in the olfactory epithelium)

doi: 10.1523/JNEUROSCI.4655-13.2014 80 LiD.UetaE.KimuraT.YamamotoT.OsakiT

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Together, these data indicate that NSCLC cells retain the capacity to synthesize Fe-S clusters within the mitochondria in the absence of an extracellular cysteine source

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