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Serine and glycine are needed for cysteine synthesis in one-carbon metabolism, and serine-derived glycine is preferentially used by cancer cells over exogenous glycine

Indeed, many mitochondrial pathways generate ROS as a sort of undesired side-product, and most of those pathways, such as respiratory complexes, are deeply involved in bioenergetics

In addition, PTH initiates the production of the steroid hormone calcitriol (also known as 1,25-dihydroxyvitamin D), which is the active form of vitamin D3, in the kidneys

Previously, we showed that the sensitivity of ARID1A-deficient cells to eprenetapopt (APR-246) is independent of TP53 status 15