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Each biological process presented in this systematic review that is epigenetically regulated by DNA methylation may have great significance in endometriosis onset, but individually, they may not be sufficient to explain the development and/or progression of the disease

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However, so far, there is still one study examined the salivary levels of miR-153 and miR-223, requiring further validation to confirm their noninvasive diagnostic value for PD

However, there are limitations involving liver biopsies as well due to the inter-pathologist variability in interpretation of grades and degree of steatosis, inflammation and fibrosis (92,124)

Often the patient does not want to believe they have a genetic affliction and will seek another diagnosis