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Grabner, A

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Chrysin selectively downregulates MMP-10, demonstrating potent anti-metastatic effects in triple-negative breast cancer (TNBC) models (Monsef-Esfahani et al., 2014) Nepitrin, even at low concentrations, directly inhibits the enzymatic activity of MMP-2 and MMP-9, thereby attenuating proteolytic ECM remodeling (Yao et al., 2019), while luteolin suppresses MMP-2/9 expression to impair migration and invasion of cells of colorectal cancer and breast cancer (Li et al., 2015)

This work was supported by the Agence Nationale de la Recherche (France 2030 programme 21-ESRE-0028, ESR/Equipex+ Onco-Pheno-Screen