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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., 2008)

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In hereditary hemochromatosis, downregulation of the cystine-glutamate transporter directly exacerbates ferroptosis-driven liver injury, while N-acetylcysteine supplementation restores glutathione levels and inhibits ferroptotic cell death [54]

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Despite the availability of various treatment options, many patients experience inadequate relief or intolerable side effects

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[19] GSH is capable of preventing infection from the influenza virus

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Grains and Legumes: Whole wheat bread, pasta, and lentils contain moderate amounts, though this can vary based on soil content

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