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[10] Some authors have broadened the definition of the Michael addition to essentially refer to any 1,4-addition reaction of ,-unsaturated carbonyl compounds

Importantly, ZSWIM8 binding appears incompatible with conformations observed for AGO2miRNA complexes not engaged with a TDMD trigger, as the PAZ and N domains would either clash with or fail to contact ZSWIM8 (refs

doi: 10.1016/j.taap.2009.08.028

In another similar report, Sagwal et al

In the lorcaserin group, 22.6% of patients lost at least 10% of their body weight, as compared to 9.7% of patients in the placebo group [84]

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