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Models of diffuse white matter lesions Since their original description by Alzheimer and Binswanger, WM lesions in cSVD have been thought to result from chronic hypoxic hypoperfusion (see section 3.2)

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However, the top 20 most statistically significantly regulated brain regions in response to treatment were analysed as previously described 37

Vitamin B12 (cobalamin) injections are a form of intramuscular treatment used to rapidly restore and maintain adequate B12 levels in the body

Moreover, excessive mitochondrial fusion and the absence of mitochondrial division have been observed in various cellular senescence models

doi: 10.3389/fmed.2016.00038 23