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The sustained cAMP elevation activates critical survival pathways in RGCs, most notably through the potentiation of Brain-Derived Neurotrophic Factor (BDNF) signaling

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Since genetic manipulations (e.g., knockdown, knockout, overexpression, etc.) are not possible in RBCs, pharmacological modulation of surface and intracellular proteins by specific antibodies, inhibitors, and agonists remains the only currently available approach
