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however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages

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10.3389/fcimb.2023.1102462 12 BoitzJ

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There is a pressing need for standardized diagnostics and longitudinal studies to clarify the temporal relationship between microbiome changes and disease onset, as well as to identify reliable microbial or metabolic biomarkers for early detection and targeted intervention (Liu T

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Gut 33:11131117 Chapman WC, Peterkin GA 3rd, LaMorte WW, Williams LF Jr (1989) Alterations in biliary motility correlate with increased gallbladder prostaglandin synthesis in early cholelithiasis in prairie dog

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& Kulka, M

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Epigenetic reprogramming in mammalian development

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