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Countering glutamate-induced 12-Lox S -glutathionylation by glutaredoxin-1 overexpression protected against cell death

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In our study, it was found that ethanol exposure resulted in significant loss of synaptic markers SYP and PSD95, as well as decrease in BDNF levels in the hippocampus of APP/PS1 mice, indicating the accumulated neural damages caused by chronic ethanol exposure at molecular level