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Interestingly, we found that both ferrostatin-1, a ferroptosis inhibitor 41 and 48c reduced the endogenous lipid peroxidation level in HK-2 cells and inhibition of IRE1 expression had similar but intermediate effects (Supplementary Fig

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Additionally, in a high-fat diet-induced hypertension mouse model, valproic acid was found to inhibit HDAC1, reducing angiotensin II and its receptor expression, thereby preventing hypertension progression [79]

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