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Notably, engineered EVs show promise as biocompatible drug carriers to overcome therapeutic resistance [53,54] , with strategies like peptide-functionalized bacterial EVs demonstrating targeted miRNA delivery efficacy in bone diseases [58] , reinforcing the potential of engineered EVs to overcome therapeutic resistance

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Grek, C

GHK-Cu is a naturally occurring tripeptide complex glycyl-L-histidyl-L-lysine that binds copper(II) ions with high affinity

6 Conclusion Gastric cancer is the third leading cause of cancer-related death worldwide

Standard Dosing Ranges The most extensively studied dosing protocols for subcutaneous administration include: Research-Based Dosing Protocols Beginner/Conservative Protocol: Dose: 250-300 mcg once daily Duration: 4-8 weeks initial assessment period Rationale: Allows tolerance assessment and response evaluation at lower end of therapeutic range Standard Protocol: Dose: 300-500 mcg once daily Duration: 12-24 weeks based on clinical trials Rationale: Most commonly studied range in human research with optimal benefit-to-safety ratio Advanced Protocol: Dose: 500 mcg-1 mg once daily Duration: 12-24 weeks under close medical monitoring Rationale: Upper clinical range