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While glutathione is present in all cells, its highest concentration is found in the liver, where it plays an absolutely indispensable role in the body's primary detoxification pathways
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It is possible that the LKB1/AMPK/ACC pathway is activated by direct redox modulation of cellular proteins since activation of AMPK pathway has been directly linked to cellular redox status and hydrogen peroxide 49
In addition, liver-specific FGF4 knockout mice were more prone to accumulate lipid peroxides and free iron, leading to more severe liver damage and inflammation
