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Dargent A, et al

Beyond thyroidal hyperfunction, Graves disease may manifest with extra-thyroidal complications, most notably thyroid-associated orbitopathy, in which fibroblasts and preadipocytes in the orbit express the TSHR and insulin-like growth factor 1 receptor (IGF-1R), leading to tissue expansion, edema, and fibrosis under autoantibody stimulation [19,20]

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Silva JPB, Navegantes-Lima KC, Oliveira ALB, Rodrigues DVS, Gaspar SLF, Monteiro VVS, Moura DP, Monteiro MC

Additionally, vitamin B12 deficiency can cause neurocognitive manifestations including depression, episodes of psychosis, delirium, dementia, poor memory performance, and cognitive impairment (, , )
