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This reduction in NAD decreases ATP production and leads to defects in DNA repair, as NAD is essential for PARP-1 activity, which increases the accumulation of genetic damage and potentially contributes to the development of neurodegenerative diseases (198, 208)

^ a b c d e f g h i j k l m n o Heilman D., Woski S., Voet D., Voet J.G., Pratt C.W

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Organic acids (lactic, citric acid or a 1:1 mixture of both) could also be used as a pre-treatment reagent to remove residues (scales, bones, meat or fat) [55]

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Theodore M., Kawai Y., Yang J., Kleshchenko Y., Reddy S.P., Villalta F., Arinze I.J

Summarizing the induction of apoptosis results, it should be emphasized that the studied extract induced activation of both intrinsic and extrinsic apoptosis pathways, wherein the extrinsic pathway eventually amplified the intrinsic pathway through the caspase-8-mediated truncation of Bid