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add on to other therapeutic schemes)

Sin A enhances thermogenesis in adipose tissue via SLIT3 upregulation in M2-like macrophages and sympathetic neuron-derived norepinephrine Adipose-resident M2-like macrophages secrete SLIT3, a cytokine that activates PKAcalciumcalmodulin-dependent protein kinase II (CaMKII) signaling in sympathetic neurons via roundabout guidance receptor 1 (ROBO1), subsequently increasing norepinephrine (NE) secretion 23

Psychopharmacol 152 : 181188

Cardioprotective Properties: Studies have shown that IGF-1 LR3 supports cardiovascular health by promoting cardiac development, improving heart function, and enhancing metabolic processes
Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer

Garca-Lpez M, Mora A, Corrales P, Pons T, Snchez de Diego A, Talavera Gutirrez A, et al