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Stepwise one-electron reductions of O 2 yield O 2 , which yields hydrogen peroxide (H 2 O 2 ) and finally converts to OH ( 2 O 2 produced from O 2 can be detoxified by mitochondrial or cytoplasmic catalase or can yield the highly diffusible H 2 O 2

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In inducing apoptosis in human lymphoma cells, Sag has shown to selectively activate programmed cell death in sensitive cell lines, providing evidence for its potential as a new inducer of lymphoma cell apoptosis

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