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Collectively, these efforts are converging to transform the zebrafish from a primarily phenomenological screening tool into a predictive and integrative translational platform

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This effect is partly mediated through upregulation of anti-apoptotic proteins such as B-cell lymphoma 2 (Bcl-2), and downregulation of pro-apoptotic proteins such as tumour protein 53 and Bcl-2-associated X protein, collectively enhancing neuronal survival [50]

This process requires various nutrients, including vitamins B6, B12, and folate, as well as minerals like selenium

Strikingly, a high number of proteins more than 80% from all models exhibited differential mean expression between control and cKOt mice (Figure 1J), demonstrating the substantial effect of Bmal1 deletion on the renal proteome

EGCG can effectively prevent the downregulation of A [53]