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The mechanism is independent of its diuretic properties as it solely relies on off-target tissue mechanisms

Hulgan, T

Moreover, microglial cells (MGCs), a primary source of GLP-1 secretion in the brain, have been implicated in early neurodegeneration in diabetic mouse models (144), highlighting the GLP-1-mediated impact on cognitive function

FEBS Lett 593:21392150 Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T (2013) Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria

doi: 10.1016/j.redox.2023.102624

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