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This change may significantly contribute to the development of insulin resistance in the brain (2628)

Unlike peptides that require brain penetration, klotho enhances cognition when administered peripherallydespite not crossing the blood-brain barriersuggesting it acts through systemic signaling mechanisms that remain incompletely understood

Diabetes mellitus classifications include type 1 insulin-dependent, type 2 insulin-independent, gestational diabetes, and other less common types (e.g., MODY) [1]

Intestinal claudins exist in two functionally different classes: sealing claudins, responsible for the tightness, and pore-forming claudins (71)

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Months 4-6: Anti-aging effects accumulate