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Because of the negative effect of this axis on oxidative phosphorylation, we studied whether it regulates EC mitochondrial function

These ROS can damage the cell structure, cause cell death and dysfunction, and ultimately exacerbate muscle atrophy [33]

Wang H, Lu Z, Lin X, Wang M, Jiang T, Zhao G, La X, Xv J, Jiang S, Zhang G (2023a) The n-terminal hydrophobicity modulates a distal structural domain conformation of zearalenone lacton hydrolase and its application in protein engineering

In mice, knockout of ChREBP has been shown to reduce hepatic fatty acid synthesis by 65% compared to wild-type controls, but also to promote insulin resistance, delayed glucose clearance, and severe intolerance to simple carbohydrates, such as sucrose and fructose (resulting in death in the majority of animals) due to an inability to shunt fructose into glycolytic pathways [48]

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2

As the key driver oncogene of PDAC, KRAS has been reported to upregulate FSP1 expression to confer ferroptosis resistance and facilitate the establishment of PDAC