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Taken together, the appreciable target specificity and favourable safety profile support the suitability of B-017 as a potential therapeutic agent

Ameen SSM, Algethami FK, Omer KM (2025) Boosting ratiometric fluorescence detection via dual-antenna and Bi-ligand strategies in a dual-emission Eu-MOF probe

doi: 10.1111/dth.15331

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They are not interchangeable with other preparations of botulinum toxin products and, therefore, Units of biological activity of BOTOX cannot be compared to nor converted into Units of any other botulinum toxin products assessed with any other specific assay method

Introduction Our group was the first to describe in humans the existence of an intrinsichypothalamic-somatotrophic rhythm, sexually dimorphic, that conditions the secretion of growth hormone (GH) ( We currently know that GH is a pleiotropic hormone that, in addition to its metabolic and growth effects, has very important positive effects on practically all organs and tissues ( GH expression has been shown to exist at many extra-pituitary sites, including the nervous system, reproductive system, immune system, cardiovascular system, muscle tissue, dermal tissue, skeletal tissue, and even in the eyes ( It seems logical, then, that both the knowledge of the multiple functions that GH plays in the body and the peripheral expression of the hormone have increased the knowledge of the complexity of GH regulation, far beyond the classical concept ( Ghrelin In 1990 it was published that a synthetic hexapeptide called GH-releasing peptide (GHRP) could act as a potent GH secretagogue in normal humans ( Figure 1