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In addition, VD up-regulates the expression of claudin-5/ZO-1 tight junction proteins through OPN-mediated Akt/p42/p44/MAPK phosphorylation, FAK/PI3 K/Akt and CD44/P-gp glycosylation pathways, which has protective effects against BBB dysfunction and apoptotic neuronal cell death [103,104,105]
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The peptide appears to influence sleep stages in ways that alter dream intensity and recall
