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Plasma Trimethylamine N-oxide as a novel biomarker for plaque rupture in patients with ST-segment-elevation myocardial infarction

64 Gabrielli, M., Ojetti, V., Candelli, M., Santarelli, L., Gasbarrini, A

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Groups of mostly medium- and long-chain ACs were found to be associated with all-cause mortality or all-cause hospitalization when adjusted for known predictors of each outcome
Several interrelated mechanisms likely underlie this dysregulation, including the hyperglycemic microenvironment, insulin resistance, chronic oxidative stress, and progressive renal structural damage, which collectively impair carnitine homeostasis through multidimensional and cascading pathophysiological mechanisms