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Therefore, it can be concluded that spirulina in doses equal 100500 mg/kg alleviate cyclophosphamide-induced cystitis and nephrotoxicity in animals (Eltantawy et al., 2018)

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In the past, FDA has declined to add these substances to the bulk compounding list because of safety and/or efficacy concerns

The observed lesions such as rapture, sloughing off of meninges, and hemorrhage was indicative of primary injury while the inflammatory responses that may cause neuronal loss, axonal injury, and impairment of synaptic plasticity indicate the secondary injury process (Andres et al., 2014)