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While histamine is involved with pro-inflammatory pathways, when subject to inflammatory conditions (such as treatment with LPS inflammogen), histamine inhibits chronic microglia activation and exhibits downregulatory effects [58]

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Lancet 400, 11451156

bioRxiv2026 Jan 24

In hypoxia, the increased expression of the mitochondrial gene might involve the phosphorylation of the AKT signaling pathway, rather than the activation of ERK that is activated in a traumatic neuronal injury through PKC (77)