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Therefore, the severity of AD is classified from mild to severe according to various clinical scales such as the Eczema Area and Severity Index (EASI), the Investigator Global Evaluation (IGA), the Three Item Severity Score (TIS), and the SCORing Atopic Dermatitis (SCORAD) scales ( AD is associated with several comorbidities, both allergic and non-allergic, indicating its systemic nature, particularly bacterial and fungal infections, neuropsychiatric disorders, autoimmune diseases, metabolic diseases and haematologic malignancies ( AD can be distinguished into extrinsic and intrinsic

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