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The available treatments for AA, such as corticosteroids and other immunomodulators, minoxidil, and contact immunotherapy, are of limited efficacy with a high risk of adverse effects and high recurrence rates, especially for patients with severe AA

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2.3 Classification by tissue specificity 2.3.1 Hematopoietic stem cells HSCs are a class of adult stem cells capable of self-renewal and differentiation into all blood cell lineages and immune cells

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Buneeva O., Fedchenko V., Kopylov A., Medvedev A

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA