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Am J Anat 23(1):3788 Rivilis I et al (2002) Differential involvement of MMP-2 and VEGF during muscle stretch-versus shear stress-induced angiogenesis

established that GHK and other peptides containing the GHK sequence demonstrated strong angiogenic activity, leading the researchers to conclude that copper peptides such as GHK-Cuand especially the sequence (K)GHKcan regulate angiogenesis in vivo [8]

doi: 10.1111/prd.12083

Moreover, the extract maintained the antioxidant defense, preserving the levels of reduced glutathione and protein thiol (52)

This framework helps distinguish whether an individual has actual nutrient insufficiency, mitochondrial stress, or metabolic dysfunction that might benefit from component-level support versus lifestyle intervention alone

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