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Curcumin represses colorectal cancer cell proliferation by triggering ferroptosis via PI3K/Akt/mTOR signaling

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doi: 10.1038/s41392-023-01481-w, 18

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10.1093/jn/138.9.1602 95 Gruji-MilanoviJ.JaeviV.MiloradoviZ.MilanoviS

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In a primary prevention study among 3,629 cognitively healthy older adults, the Prevention of Alzheimers Disease by Vitamin E and Selenium (PREADViSE) trial, vitamin E supplementation (400 IU/day of supplemental all - rac --tocopheryl acetate [180 mg/day of RRR --tocopherol]) for a mean of 5.4 years had no benefit on prevention of dementia (113)

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IGF-1, structurally similar to insulin except for its interaction with IGF-1R, can also bind the insulin receptor (IR) and vice versa (41)

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